RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells

RGS5 Attenuates Baseline Activity of ERK1/2 and Promotes Growth Arrest of Vascular Smooth Muscle Cells

The regulator of G-protein signaling 5 (RGS5) acts as an inhibitor of Gα<sub>q/11</sub> and Gα<sub>i/o</sub> activity in vascular smooth muscle cells (VSMCs), which regulate arterial tone and blood pressure. While RGS5 has been described as a crucial determinant regulating th...

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Bibliographic Details
Main Authors: Eda Demirel, Caroline Arnold, Jaspal Garg, Marius Andreas Jäger, Carsten Sticht, Rui Li, Hanna Kuk, Nina Wettschureck, Markus Hecker, Thomas Korff
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cells
Subjects:
RGS proteins
G-protein signaling
VSMC phenotype
ERK1/2
blood pressure
Online Access:https://www.mdpi.com/2073-4409/10/7/1748

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https://www.mdpi.com/2073-4409/10/7/1748

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