An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Human immunodeficiency virus type 1 (HIV-1) is characterized by high variability and drug resistance. This has necessitated the development of antivirals with a new chemotype and therapy. We previously identified an artificial peptide with non-native protein sequence, AP3, with the potential to inhi...

Full description

Bibliographic Details
Main Authors: Chao Wang, Qing Li, Lujia Sun, Xinling Wang, Huan Wang, Wenpeng Zhang, Jiahui Li, Yang Liu, Lu Lu, Shibo Jiang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Viruses
Subjects:
HIV-1
gp41
CCR5
entry inhibitors
multitarget-directed ligands
coiled coil
Online Access:https://www.mdpi.com/1999-4915/15/5/1038

Internet

https://www.mdpi.com/1999-4915/15/5/1038

Similar Items