The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model

The effect of drug holiday on preventing medication-related osteonecrosis of the jaw in osteoporotic rat model

Background: Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication associated with antiresorptive medications managing osteoporosis, such as bisphosphonates (BPs). To date, there is very limited evidence from prospective, controlled studies to support or refute the controversia...

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Bibliographic Details
Main Authors: Wang-yong Zhu, Wei-fa Yang, Leilei Wang, Xinmiao Lan, Zhuo-ying Tao, Jiaxin Guo, Jiankun Xu, Ling Qin, Yu-xiong Su
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Orthopaedic Translation
Subjects:
Medication-related osteonecrosis of the jaw
Osteoporosis
Bisphosphonate
Drug holiday
Osteoclast
Bone turnover
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X22001565

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http://www.sciencedirect.com/science/article/pii/S2214031X22001565

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