The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO‐Mediated Nuclear Export of ZEB1 mRNA

The Conserved LncRNA DIO3OS Restricts Hepatocellular Carcinoma Stemness by Interfering with NONO‐Mediated Nuclear Export of ZEB1 mRNA

Abstract Hepatocellular carcinoma (HCC) is an aggressive and fatal disease caused by a subset of cancer stem cells (CSCs). It is estimated that there are approximately 100 000 long noncoding RNAs (lncRNAs) in humans. However, the mechanisms by which lncRNAs affect tumor stemness remain poorly unders...

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Bibliographic Details
Main Authors: Ya‐Rui Hou, Li‐Ting Diao, Yan‐Xia Hu, Qian‐Qian Zhang, Guo Lv, Shuang Tao, Wan‐Yi Xu, Shu‐Juan Xie, Qi Zhang, Zhen‐Dong Xiao
Format: Article
Language:English
Published: Wiley 2023-08-01
Series:Advanced Science
Subjects:
cancer stemness
hepatocellular carcinoma
lncRNA DIO3OS
mRNA subcellular distribution
NONO
ZEB1
Online Access:https://doi.org/10.1002/advs.202301983

Internet

https://doi.org/10.1002/advs.202301983

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