Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

T cell development involves extensive proliferation of developing thymocytes. Here, the authors demonstrate that the transcription factor Zfp335 regulates the survival post-β-selection thymocytes via the cGAS/STING pathway.

Bibliographic Details
Main Authors: Jeremy J. Ratiu, William E. Barclay, Elliot Lin, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa J. Harnois, Devon DiPalma, Sumedha Roy, Alejandra V. Contreras, Mari L. Shinohara, David Wiest, Yuan Zhuang
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33610-4

Internet

https://doi.org/10.1038/s41467-022-33610-4

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