Fetal drug exposure after maternally administered CFTR modulators Elexacaftor/Tezacaftor/Ivacaftor in a rat model

Fetal drug exposure after maternally administered CFTR modulators Elexacaftor/Tezacaftor/Ivacaftor in a rat model

Background: The potential effects of the very effective cystic fibrosis triple combination drug, Elexacaftor/Tezacaftor/Ivacaftor (ETI) in pregnancy on prenatal development of offspring remain largely unknown. Research question: We aimed to investigate the fetal tissue distribution pattern of matern...

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Bibliographic Details
Main Authors: Danni Li, Yimin Zhu, Martin Donnelley, David Parsons, Mark D. Habgood, Elena K. Schneider-Futschik
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cystic fibrosis
CFTR modulators
Drug accumulation
Elexacaftor/Tezacaftor/Ivacaftor
Fetal drug exposure
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224000362

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http://www.sciencedirect.com/science/article/pii/S0753332224000362

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