Rapid Molecular Response to Dasatinib in a Pediatric Relapsed Acute Lymphoblastic Leukemia With NCOR1-LYN Fusion

Rapid Molecular Response to Dasatinib in a Pediatric Relapsed Acute Lymphoblastic Leukemia With NCOR1-LYN Fusion

Background: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is associated with high rates of treatment failure and poor outcome. Activation of ABL/Src family kinases is found in ~10% of Ph-like ALL, which can be therapeutically targeted by tyrosine kinase inhibitors. LYN is a...

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Bibliographic Details
Main Authors: Hai-Ping Dai, Jia Yin, Zheng Li, Chun-Xiao Yang, Tin Cao, Ping Chen, Yun-Hui Zong, Ming-Qing Zhu, Xia-Ming Zhu, Sheng Xiao, De-Pei Wu, Xiao-Wen Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
NCOR1-LYN
fusion gene
dasatinib
ALL
pediatric
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00359/full

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https://www.frontiersin.org/article/10.3389/fonc.2020.00359/full

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