Modeling the Transition From Decompensated to Pathological Hypertrophy
BackgroundLong‐chain acyl‐CoA synthetases (ACSL) catalyze the conversion of long‐chain fatty acids to fatty acyl‐CoAs. Cardiac‐specific ACSL1 temporal knockout at 2 months results in a shift from FA oxidation toward glycolysis that promotes mTORC1‐mediated ventricular hypertrophy. We used unbiased m...
| Главные авторы: | , , , , |
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| Формат: | Статья |
| Язык: | English |
| Опубликовано: |
Wiley
2018-04-01
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| Серии: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Предметы: | |
| Online-ссылка: | https://www.ahajournals.org/doi/10.1161/JAHA.117.008293 |