Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model

Surface functionalization affects the retention and bio-distribution of orally administered mesoporous silica nanoparticles in a colitis mouse model

Abstract Besides the many advantages of oral drug administration, challenges like premature drug degradation and limited bioavailability in the gastro-intestinal tract (GIT) remain. A prolonged residence time in the GIT is beneficial for enhancing the therapeutic outcome when treating diseases assoc...

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Bibliographic Details
Main Authors: Roman Schmid, Meta Volcic, Stephan Fischer, Zhi Qu, Holger Barth, Amirali Popat, Frank Kirchhoff, Mika Lindén
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47445-6

Internet

https://doi.org/10.1038/s41598-023-47445-6

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