<i>SLCO1B1</i> Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia

<i>SLCO1B1</i> Genetic Variation Influence on Atorvastatin Systemic Exposure in Pediatric Hypercholesterolemia

This clinical study examined the influence of <i>SLCO1B1</i> c.521T>C (rs4149056) on plasma atorvastatin concentrations in pediatric hypercholesterolemia. The participants (8–21 years), including heterozygous (c.521T/C, n = 13), homozygous (c.521C/C, n = 2) and controls (c.521T/T, n =...

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Bibliographic Details
Main Authors: Jonathan B. Wagner, Susan Abdel-Rahman, Geetha Raghuveer, Andrea Gaedigk, Erin C. Boone, Roger Gaedigk, Vincent S. Staggs, Gregory A. Reed, Na Zhang, J. Steven Leeder
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Genes
Subjects:
cholesterol
lipids
pediatrics
pharmacogenomics
pharmacokinetics
statins
Online Access:https://www.mdpi.com/2073-4425/15/1/99

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https://www.mdpi.com/2073-4425/15/1/99

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