Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy

Glycolytic potential enhanced by blockade of pyruvate influx into mitochondria sensitizes prostate cancer to detection and radiotherapy

Objective: This study aimed to evaluate the effects of mitochondrial pyruvate carrier (MPC) blockade on the sensitivity of detection and radiotherapy of prostate cancer (PCa). Methods: We investigated glycolysis reprogramming and MPC changes in patients with PCa by using metabolic profiling, RNA-Seq...

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Bibliographic Details
Main Authors: Huan Xu, Junyi Chen, Zhi Cao, Xi Chen, Caihong Huang, Jin Ji, Yalong Xu, Junfeng Jiang, Yue Wang, Guowang Xu, Lina Zhou, Jingyi He, Xuedong Wei, Jason Boyang Wu, Zhong Wang, Shancheng Ren, Fubo Wang
Format: Article
Language:English
Published: China Anti-Cancer Association 2022-09-01
Series:Cancer Biology & Medicine
Subjects:
glycolytic potential
prostate cancer
mitochondrial pyruvate carrier (mpc)
mitochondria pyruvate influx
diagnosis
radiotherapy
Online Access:https://www.cancerbiomed.org/content/19/9/1315

Internet

https://www.cancerbiomed.org/content/19/9/1315

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