Synergistic cytotoxicity of fludarabine, clofarabine, busulfan, vorinostat and olaparib in AML cells

Synergistic cytotoxicity of fludarabine, clofarabine, busulfan, vorinostat and olaparib in AML cells

Combinations of nucleoside analog(s) and DNA alkylating agent(s) are used for cancer treatment as components of pre-transplant regimens used in hematopoietic stem cell transplantation. Their efficacies are enhanced by combining drugs with different mechanisms of action, which also allows a reduction...

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Bibliographic Details
Main Authors: Benigno C. Valdez, Bin Yuan, David Murray, Jeremy Leon Ramdial, Yago Nieto, Uday Popat, Xiaowen Tang, Borje S. Andersson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
alkylating agent
nucleoside analog
HDAC inhibitor
PARP inhibitior
stem cell transplant (SCT)
pre-transplant regimen
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1287444/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1287444/full

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