Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.

Multidimensional single-cell analysis of BCR signaling reveals proximal activation defect as a hallmark of chronic lymphocytic leukemia B cells.

Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation.We developed an experimental methodology combining immunoph...

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Bibliographic Details
Main Authors: M Lia Palomba, Kelly Piersanti, Carly G K Ziegler, Hugo Decker, Jesse W Cotari, Kurt Bantilan, Ivelise Rijo, Jeff R Gardner, Mark Heaney, Debra Bemis, Robert Balderas, Sami N Malek, Erlene Seymour, Andrew D Zelenetz, Marcel R M van den Brink, Grégoire Altan-Bonnet
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3906024?pdf=render

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http://europepmc.org/articles/PMC3906024?pdf=render

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