Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities

Novel Pan-Pim Kinase Inhibitors With Imidazopyridazine and Thiazolidinedione Structure Exert Potent Antitumor Activities

Pim kinases are overexpressed in various types of hematological malignancies and solid carcinomas, and promote cell proliferation and survival. Here in this study, we investigated the preclinical profile of novel pan-Pim kinase inhibitors with imidazopyridazine and thiazolidinedione structure. Imida...

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Bibliographic Details
Main Authors: Yuichi Sawaguchi, Ryuta Yamazaki, Yukiko Nishiyama, Masayuki Mae, Atsuhiro Abe, Hiroyuki Nishiyama, Fukiko Nishisaka, Tatsuya Ibuki, Toshio Sasai, Takeshi Matsuzaki
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
pim kinase
imidazopyridazine
thiazolidinedione
pan-pim kinase inhibitor
anticancer drug
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.672536/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.672536/full

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