Dynamics Rationalize Proteolytic Susceptibility of the Major Birch Pollen Allergen Bet v 1

Dynamics Rationalize Proteolytic Susceptibility of the Major Birch Pollen Allergen Bet v 1

Proteolytic susceptibility during endolysosomal degradation is decisive for allergic sensitization. In the major birch pollen allergen Bet v 1 most protease cleavage sites are located within its secondary structure elements, which are inherently inaccessible to proteases. The allergen thus must unfo...

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Bibliographic Details
Main Authors: Anna S. Kamenik, Florian Hofer, Philip H. Handle, Klaus R. Liedl
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Molecular Biosciences
Subjects:
allergen proteins
molecular dynamics simulations
unfolding
proteolytic cleavage
enhanced sampling
Markov state models
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00018/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2020.00018/full

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