Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner

Copper ions, prion protein and Aβ modulate Ca levels in central nervous system myelin in an NMDA receptor-dependent manner

Abstract As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic nerves, we show that Cu ions potently modulate Ca l...

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Bibliographic Details
Main Authors: Shigeki Tsutsui, Megan Morgan, Hugo Tedford, Haitao You, Gerald W. Zamponi, Peter K. Stys
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Molecular Brain
Subjects:
Alzheimer's disease
Bathocuproine
Proteolipid protein
Glutamate receptor
Online Access:https://doi.org/10.1186/s13041-022-00955-2

Internet

https://doi.org/10.1186/s13041-022-00955-2

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