The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study

The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study

<i>Background</i>: LGR5 is one of the most important stem cell markers for colorectal cancer (CRC), as it potentiates Wnt/Β-catenin signaling. The well-characterized deregulation of Wnt/Β-catenin signaling that occurs during adenoma/carcinoma sequence in CRC renders LGR5 a hopeful therap...

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Bibliographic Details
Main Authors: Eman Mohamed Ahmed, Abeer Said Farag, Mohammed S. Abdelwahed, Mehenaz Hanbazazh, Abdulhadi Samman, Diaa Ashmawy, Nageh Rady Abd-Elhameed, Mohamed Tharwat, Alyaa E. Othman, Taiseer Ahmed Shawky, Radwa Mohamed Attia, Adel Abdelwahid Ibrahim, Sherif Azzam, Mohammed E. A. Elhussiny, Mohamed Nasr, Suhaib Alsayed Naeem, Wagih M. Abd-Elhay, Ahmed Mohammad Ali Alfaifi, Abdulkarim Hasan
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Medicina
Subjects:
colorectal cancer
cancer stem cell
LGR5
Β-catenin
immunohistochemistry
Online Access:https://www.mdpi.com/1648-9144/59/7/1233

Internet

https://www.mdpi.com/1648-9144/59/7/1233

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