Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery

Dual thick and thin filament linked regulation of stretch- and L-NAME-induced tone in young and senescent murine basilar artery

Stretch-induced vascular tone is an important element of autoregulatory adaptation of cerebral vasculature to maintain cerebral flow constant despite changes in perfusion pressure. Little is known as to the regulation of tone in senescent basilar arteries. We tested the hypothesis, that thin filamen...

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Bibliographic Details
Main Authors: Lubomir T. Lubomirov, Mechthild M. Schroeter, Veronika Hasse, Marina Frohn, Doris Metzler, Maria Bust, Galyna Pryymachuk, Jürgen Hescheler, Olaf Grisk, Joseph M. Chalovich, Neil R. Smyth, Gabriele Pfitzer, Symeon Papadopoulos
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Physiology
Subjects:
stretch-induced tone
senescence
basilar artery
non-muscle myosin
caldesmon
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2023.1099278/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2023.1099278/full

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