Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans

Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans

Echinochrome A, a natural naphthoquinone pigment found in sea urchins, is increasingly being investigated for its nutritional and therapeutic value associated with antioxidant, anticancer, antiviral, antidiabetic, and cardioprotective activities. Although several studies have demonstrated the biolog...

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Bibliographic Details
Main Authors: Dong-Gyun Han, Jinsook Kwak, Eugene Choi, Seong-Wook Seo, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Jin Han, Jong Hyuk Byun, Il Hyo Jung, Hwayoung Yun, In-Soo Yoon
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Echinochrome A
Physicochemical characterization
Metabolic profiling
Glucuronidation
Methylation
PBPK model
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223003773

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http://www.sciencedirect.com/science/article/pii/S0753332223003773

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