Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans

Physicochemical characterization and phase II metabolic profiling of echinochrome A, a bioactive constituent from sea urchin, and its physiologically based pharmacokinetic modeling in rats and humans

Echinochrome A, a natural naphthoquinone pigment found in sea urchins, is increasingly being investigated for its nutritional and therapeutic value associated with antioxidant, anticancer, antiviral, antidiabetic, and cardioprotective activities. Although several studies have demonstrated the biolog...

Full description

Bibliographic Details
Main Authors:	Dong-Gyun Han, Jinsook Kwak, Eugene Choi, Seong-Wook Seo, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Hyoung Kyu Kim, Jin Han, Jong Hyuk Byun, Il Hyo Jung, Hwayoung Yun, In-Soo Yoon
Format:	Article
Language:	English
Published:	Elsevier 2023-06-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Echinochrome A Physicochemical characterization Metabolic profiling Glucuronidation Methylation PBPK model
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332223003773

Similar Items

Multifaceted Clinical Effects of Echinochrome
by: Hyoung Kyu Kim, et al.
Published: (2021-07-01)

Acetylcholinesterase Inhibitory Activity of Pigment Echinochrome A from Sea Urchin Scaphechinus mirabilis
by: Sung Ryul Lee, et al.
Published: (2014-06-01)

Echinochrome A Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat
by: Ran Kim, et al.
Published: (2019-08-01)

Echinochrome A Reverses Kidney Abnormality and Reduces Blood Pressure in a Rat Model of Preeclampsia
by: Huixing Cui, et al.
Published: (2022-11-01)

The Protective Effect of Echinochrome A on Extracellular Matrix of Vocal Folds in Ovariectomized Rats
by: Ji Min Kim, et al.
Published: (2020-01-01)

Echinochrome A Increases Mitochondrial Mass and Function by Modulating Mitochondrial Biogenesis Regulatory Genes
by: Seung Hun Jeong, et al.
Published: (2014-08-01)

Antiviral and Antioxidant Properties of Echinochrome A
by: Sergey A. Fedoreyev, et al.
Published: (2018-12-01)

Isolation and Structure Determination of Echinochrome A Oxidative Degradation Products
by: Natalia P. Mishchenko, et al.
Published: (2020-10-01)

Echinochrome A Improves Exercise Capacity during Short-Term Endurance Training in Rats
by: Dae Yun Seo, et al.
Published: (2015-09-01)

Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma
by: Gyu-Tae Park, et al.
Published: (2021-04-01)

Echinochrome A Inhibits Melanogenesis in B16F10 Cells by Downregulating CREB Signaling
by: Mi Ran Choi, et al.
Published: (2022-08-01)

Multiple Effects of Echinochrome A on Selected Ion Channels Implicated in Skin Physiology
by: Sung Eun Kim, et al.
Published: (2023-01-01)

Regulation of Inflammation-Mediated Endothelial to Mesenchymal Transition with Echinochrome a for Improving Myocardial Dysfunction
by: Byeong-Wook Song, et al.
Published: (2022-11-01)

A Novel Atypical PKC-Iota Inhibitor, Echinochrome A, Enhances Cardiomyocyte Differentiation from Mouse Embryonic Stem Cells
by: Hyoung Kyu Kim, et al.
Published: (2018-06-01)

Implication of Echinochrome A in the Plasticity and Damage of Intestinal Epithelium
by: Ji-Su Ahn, et al.
Published: (2022-11-01)

Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells
by: Su-Jeong Oh, et al.
Published: (2019-10-01)

Echinochrome A Protects against Ultraviolet B-induced Photoaging by Lowering Collagen Degradation and Inflammatory Cell Infiltration in Hairless Mice
by: Jung Eun Seol, et al.
Published: (2021-09-01)

Development of Novel Pharmaceutical Forms of the Marine Bioactive Pigment Echinochrome A Enabling Alternative Routes of Administration
by: Stefanos Kikionis, et al.
Published: (2023-04-01)

Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice
by: Xiaokang Tang, et al.
Published: (2023-01-01)

Liposomal Form of the Echinochrome-Carrageenan Complex
by: Irina M. Yermak, et al.
Published: (2018-09-01)

Echinochrome A Prevents Diabetic Nephropathy by Inhibiting the PKC-Iota Pathway and Enhancing Renal Mitochondrial Function in db/db Mice
by: Trong Kha Pham, et al.
Published: (2023-03-01)

Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC/Nga Mice via IL-4 and IL-13 Suppression
by: Hyeong Rok Yun, et al.
Published: (2021-11-01)

Hematopoietic effect of echinochrome on phenylhydrazine-induced hemolytic anemia in rats
by: Mona S. E. F. El-Shehry, et al.
Published: (2023-12-01)

The Anti-Inflammatory Effect of Carrageenan/Echinochrom Complex at Experimental Endotoxemia
by: Irina M. Yermak, et al.
Published: (2022-10-01)

Carrageenans-Sulfated Polysaccharides from Red Seaweeds as Matrices for the Inclusion of Echinochrome
by: Irina M. Yermak, et al.
Published: (2017-11-01)

Effectiveness of Echinochrome on HFD-Induced Hyperlipidemia in Rats
by: Sohair R. Fahmy, et al.
Published: (2019-10-01)

Echinochrome pigment attenuates diabetic nephropathy in the models of type 1 and type 2 diabetes
by: Amel Mahmoud Soliman, et al.
Published: (2016-12-01)

Antiherpetic Activity of Carrageenan Complex with Echinochrome A and Its Liposomal Form
by: Natalia V. Krylova, et al.
Published: (2022-12-01)

Antiviral Potential of Sea Urchin Aminated Spinochromes against Herpes Simplex Virus Type 1
by: Natalia P. Mishchenko, et al.
Published: (2020-11-01)

Echinochrome Ameliorates Physiological, Immunological, and Histopathological Alterations Induced by Ovalbumin in Asthmatic Mice by Modulating the Keap1/Nrf2 Signaling Pathway
by: Islam Ahmed Abdelmawgood, et al.
Published: (2023-08-01)

ADJUVANT EFFECT OF TUBULAR IMMUNOSTIMULATING COMPLEXES MODIFIED BY ECHINOCHROME A, TOWARDS A PORE PROTEIN FROM YERSINIA PSEUDOTUBERCULOSIS
by: A. V. Tsybulsky, et al.
Published: (2014-07-01)

Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice
by: Rebekka Fendt, et al.
Published: (2023-11-01)

Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets
by: Aleksandr A. Artyukov, et al.
Published: (2020-05-01)

Development and Evaluation of Topical Formulation Containing <i>Agrimonia pilosa</i> Extract
by: Jin Seok Lee, et al.
Published: (2023-06-01)

Pharmacokinetics of Marine-Derived Drugs
by: Alexander N. Shikov, et al.
Published: (2020-11-01)

COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN
by: A. V. Tsybulsky, et al.
Published: (2018-03-01)

Effect of Echinochrome A on Submandibular Gland Dysfunction in Ovariectomized Rats
by: Ji-Min Kim, et al.
Published: (2022-11-01)

Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics
by: Keyur R. Parmar, et al.
Published: (2023-06-01)

Therapeutic Cell Protective Role of Histochrome under Oxidative Stress in Human Cardiac Progenitor Cells
by: Ji Hye Park, et al.
Published: (2019-06-01)

A computational investigation of the ventilation structure and maximum rate of metabolism for a physiologically based pharmacokinetic (PBPK) model of inhaled xylene
by: Karen A Yokley, et al.
Published: (2019-02-01)