Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier

Expression of TFRC helps to improve the antineoplastic effect of Ara-C on AML cells through a targeted delivery carrier

Abstract Background Currently, high doses of cytarabine arabinoside (Ara-C)-based combined chemotherapy are commonly used in acute myeloid leukemia (AML) therapy, but severe adverse effects and poor suppression effects in leukemia cells limit the clinical therapeutic efficiency of Ara-C-based chemot...

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Bibliographic Details
Main Authors: Xinzhou Wu, Zhouguang Jiao, Junying Zhang, Feng Li, Yuhua Li
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Journal of Nanobiotechnology
Subjects:
Acute myeloid leukemia
Transferrin receptor
Ferritin
Targeted delivery
Ara-C
Online Access:https://doi.org/10.1186/s12951-023-01881-8

Internet

https://doi.org/10.1186/s12951-023-01881-8

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