Nicotinamide Promotes Formation of Retinal Organoids From Human Pluripotent Stem Cells via Enhanced Neural Cell Fate Commitment

Nicotinamide Promotes Formation of Retinal Organoids From Human Pluripotent Stem Cells via Enhanced Neural Cell Fate Commitment

Retinal organoids (ROs) derived from human pluripotent stem cells (hPSCs) recapitulate key features of retinogenesis and provide a promising platform to study retinal development and disease in a human context. Although multiple protocols are currently in use, hPSCs exhibit tremendous variability in...

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Bibliographic Details
Main Authors: Florian Regent, Zachary Batz, Ryan A. Kelley, Linn Gieser, Anand Swaroop, Holly Y. Chen, Tiansen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
induced pluripotent stem cells
retinal organoids
nicotinamide
BMP pathway
neuroectoderm
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2022.878351/full

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https://www.frontiersin.org/articles/10.3389/fncel.2022.878351/full

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