P53 independent pathogenic mechanisms contribute to BubR1 microcephaly

P53 independent pathogenic mechanisms contribute to BubR1 microcephaly

The mosaic variegated aneuploidy (MVA)-associated gene Budding Uninhibited by Benzimidazole 1B (BUB1B) encodes BUBR1, a core member of the spindle assembly checkpoint complex that ensures kinetochore-spindle attachment for faithful chromosome segregation. BUB1B mutation in humans and its deletion in...

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Bibliographic Details
Main Authors: Noelle A. Sterling, Bethany K. Terry, Julia M. McDonnell, Seonhee Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
BubR1
mitosis analysis
neural progenitor
p53
microcephaly
cortical development
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2023.1282182/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2023.1282182/full

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