Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS

Fast and high-throughput LC-MS characterization, and peptide mapping of engineered AAV capsids using LC-MS/MS

Adeno-associated virus (AAV) has emerged as a leading platform for gene therapy. With the skyrocketing rate of AAV research and the prevalence of many new engineered capsids being investigated in preclinical and clinical trials, capsid characterization plays a vital role in serotype confirmation and...

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Bibliographic Details
Main Authors: Anh K. Lam, Junping Zhang, Dylan Frabutt, Patrick L. Mulcrone, Lei Li, Lifan Zeng, Roland W. Herzog, Weidong Xiao
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
AAV
capsid characterization
LC-MS
peptide mapping
engineered capsids
gene therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001334

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http://www.sciencedirect.com/science/article/pii/S2329050122001334

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