Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

Influence of different formulations and process parameters during the preparation of drug-loaded PLGA microspheres evaluated by multivariate data analysis

The main objective of this study was to evaluate the influence of the formulation and process parameters on PLGA microparticles containing a practically insoluble model drug (ibuprofen) prepared by the o/w solvent evaporation method. Multivariate data analysis was used. The effects of altered stirri...

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Bibliographic Details
Main Authors: Vysloužil Jakub, Doležel Petr, Kejdušová Martina, Mašková Eliška, Mašek Josef, Lukáč Robert, Košťál Vratislav, Vetchý David, Dvořáčková Kateřina
Format: Article
Language:English
Published: Sciendo 2014-12-01
Series:Acta Pharmaceutica
Subjects:
solvent evaporation
encapsulation
plga
controlled release
burst effect
Online Access:https://doi.org/10.2478/acph-2014-0032

Internet

https://doi.org/10.2478/acph-2014-0032

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