Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone

Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone

Detailed characterization of medullary and extramedullary reservoirs of osteoclast progenitors (OCPs) is required to understand the pathophysiology of increased periarticular and systemic bone resorption in arthritis. In this study, we focused on identifying the OCP population specifically induced b...

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Bibliographic Details
Main Authors: Darja Flegar, Maša Filipović, Alan Šućur, Antonio Markotić, Nina Lukač, Dino Šisl, Marina Ikić Matijašević, Zrinka Jajić, Tomislav Kelava, Vedran Katavić, Nataša Kovačić, Danka Grčević
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Immunology
Subjects:
inflammation
myeloid cells
osteoclasts
chemokines
mouse arthritis
human arthritis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.767231/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2021.767231/full

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