Bacteroides fragilis Toxin Induces Cleavage and Proteasome Degradation of E-cadherin in Human Breast Cancer Cell Lines BT-474 and MCF7

Bacteroides fragilis Toxin Induces Cleavage and Proteasome Degradation of E-cadherin in Human Breast Cancer Cell Lines BT-474 and MCF7

Enterotoxigenic Bacteroides fragilis (ETBF) has been reported to promote colitis and colon cancer through the secretion of B. fragilis toxin (BFT), a zinc-dependent metalloprotease. In colonic epithelial cells, BFT induces the cleavage of E-cadherin into the 80 kDa ectodomain and the 33 kDa membrane...

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Bibliographic Details
Main Authors: Da-Hye KANG, Sang-Hyeon YOO, Ju-Eun HONG, Ki-Jong RHEE
Format: Article
Language:English
Published: The Korean Society for Clinical Laboratory Science 2023-03-01
Series:Korean Journal of Clinical Laboratory Science
Subjects:
enterotoxigenic bacteroides fragilis
e-cadherin
proteasome
staurosporine
Online Access:http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2023.55.1.37

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http://www.kjcls.org/journal/view.html?doi=10.15324/kjcls.2023.55.1.37

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