LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

Metabolic transformation by the superfamily of cytochromes P450 (CYPs) plays an important role in the detoxification of xenobiotics such as drugs, environmental pollutants, and food additives. Endogenous substrates of CYPs include fatty acids, sterols, steroids, and bile acids. Induction of CYPs via...

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Bibliographic Details
Main Authors: Carmela Gnerre, Gertrud U. Schuster, Adrian Roth, Christoph Handschin, Lisen Johansson, Renate Looser, Paolo Parini, Michael Podvinec, Kirsten Robertsson, Jan-Åke Gustafsson, Urs A. Meyer
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Journal of Lipid Research
Subjects:
liver X receptor
pregnane X receptor
constitutive androstane receptor
metabolism
cytochrome P450 3a11
cytochrome P450 2b10
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752032962X

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http://www.sciencedirect.com/science/article/pii/S002222752032962X

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