Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

Broadly recognized, cross-reactive SARS-CoV-2 CD4 T cell epitopes are highly conserved across human coronaviruses and presented by common HLA alleles

Summary: Sequence homology between SARS-CoV-2 and common-cold human coronaviruses (HCoVs) raises the possibility that memory responses to prior HCoV infection can affect T cell response in COVID-19. We studied T cell responses to SARS-CoV-2 and HCoVs in convalescent COVID-19 donors and identified a...

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Bibliographic Details
Main Authors: Aniuska Becerra-Artiles, J. Mauricio Calvo-Calle, Mary Dawn Co, Padma P. Nanaware, John Cruz, Grant C. Weaver, Liying Lu, Catherine Forconi, Robert W. Finberg, Ann M. Moormann, Lawrence J. Stern
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007343

Internet

http://www.sciencedirect.com/science/article/pii/S2211124722007343

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