Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

Epoxy-Oxylipins and Soluble Epoxide Hydrolase Metabolic Pathway as Targets for NSAID-Induced Gastroenteropathy and Inflammation-Associated Carcinogenesis

Polyunsaturated fatty acids (PUFAs) including epoxide-modified ω-3 and ω-6 fatty acids are made via oxidation to create highly polarized carbon-oxygen bonds crucial to their function as signaling molecules. A critical PUFA, arachidonic acid (ARA), is metabolized to a diverse set of lipids signaling...

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Bibliographic Details
Main Authors: Ryan D. Jones, Jie Liao, Xin Tong, Dandan Xu, Leyu Sun, Haonan Li, Guang-Yu Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
oxylipin
soluble epoxide hydrolase
non-steroidal anti-inflammatory drug
inflammation
carcinogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00731/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00731/full

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