Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Abstract The detailed mechanisms by which the transferrin receptor (TfR) and associated ligands traffic across brain capillary endothelial cells (BECs) of the CNS-protective blood–brain barrier constitute an important knowledge gap within maintenance and regulation of brain iron homeostasis. This kn...

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Bibliographic Details
Main Authors: Simone S. E. Nielsen, Mikkel R. Holst, Kristine Langthaler, Sarah Christine Christensen, Elisabeth Helena Bruun, Birger Brodin, Morten S. Nielsen
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Fluids and Barriers of the CNS
Subjects:
Transferrin receptor (TfR)
Intracellular trafficking
Apicobasal polarity
Brain drug delivery
Blood–brain barrier
Brain endothelial cells
Online Access:https://doi.org/10.1186/s12987-022-00404-1

Internet

https://doi.org/10.1186/s12987-022-00404-1

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