Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors: results from the EuroSIDA study

Hypersensitivity reactions, hepatotoxicity, and other discontinuations in persons receiving integrase strand transfer inhibitors: results from the EuroSIDA study

Background: Hypersensitivity reaction (HSR) and hepatotoxicity are rare, but potentially serious side-effects of antiretroviral use. Objective: To investigate discontinuations due to HSR, hepatotoxicity or other reasons among users of dolutegravir (DTG) vs. raltegravir (RAL) or elvitegravir (EVG) in...

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Main Authors: Annegret Pelchen-Matthews, Jakob Friis Larsen, Leah Shepherd, Josip Begovac, Karen Pedersen, Stéphane De Wit, Andrzej Horban, Elzbieta Jablonowska, Margaret Johnson, Irina Khromova, Marcelo H. Losso, Lars N. Nielsen, Anna Lisa Ridolfo, Brigitte Schmied, Christoph Stephan, Israel Yust, Lloyd Curtis, Vani Vannappagari, Leigh Ragone, Ashley Roen, Dorthe Raben, Ole Kirk, Lars Peters, Amanda Mocroft, for the EuroSIDA Study Group
Format: Article
Language:English
Published: Taylor & Francis Group 2021-12-01
Series:HIV Research & Clinical Practice
Subjects:
human immunodeficiency virus
antiretroviral therapy
integrase strand transfer inhibitors
dolutegravir
serious adverse events
hypersensitivity reaction
hepatotoxicity
Online Access:http://dx.doi.org/10.1080/25787489.2021.2003132

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http://dx.doi.org/10.1080/25787489.2021.2003132

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