Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation

Methylated histones on mitotic chromosomes promote topoisomerase IIα function for high fidelity chromosome segregation

Summary: DNA Topoisomerase IIα (TopoIIα) decatenates sister chromatids, allowing their segregation in mitosis. Without the TopoIIα Strand Passage Reaction (SPR), chromosome bridges and ultra-fine DNA bridges (UFBs) arise in anaphase. The TopoIIα C-terminal domain is dispensable for the SPR in vitro...

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Bibliographic Details
Main Authors: Sanjana Sundararajan, Hyewon Park, Shinji Kawano, Marnie Johansson, Bunu Lama, Tomoko Saito-Fujita, Noriko Saitoh, Alexei Arnaoutov, Mary Dasso, Zhengqiang Wang, Daniel Keifenheim, Duncan J. Clarke, Yoshiaki Azuma
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Biological sciences
Molecular biology
Chromosome organization
Molecular mechanism of gene regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223008209

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http://www.sciencedirect.com/science/article/pii/S2589004223008209

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