Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet

Although telmisartan, an angiotensin II receptor blocker (ARB), has an agonistic action for proliferator-activated receptor (PPAR)-γ in vitro, it remains to be determined whether telmisartan exerts such an action in vivo using a non-toxic dose (<5 mg/kg in rats). To address the issue, telmisartan...

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Bibliographic Details
Main Authors: Hayato Yanagihara, Kentaro Ushijima, Yusuke Arakawa, Ken-ichi Aizawa, Akio Fujimura
Format: Article
Language:English
Published: Elsevier 2016-07-01
Series:Journal of Pharmacological Sciences
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861316300731