Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model

Haemodynamic-directed cardiopulmonary resuscitation promotes mitochondrial fusion and preservation of mitochondrial mass after successful resuscitation in a pediatric porcine model

Objective: Cerebral mitochondrial dysfunction is a key mediator of neurologic injury following cardiac arrest (CA) and is regulated by the balance of fusion and fission (mitochondrial dynamics). Under stress, fission can decrease mitochondrial mass and signal apoptosis, while fusion promotes oxidati...

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Bibliographic Details
Main Authors: Kumaran Senthil, Ryan W. Morgan, Marco M. Hefti, Michael Karlsson, Andrew J. Lautz, Constantine D. Mavroudis, Tiffany Ko, Vinay M. Nadkarni, Johannes Ehinger, Robert A. Berg, Robert M. Sutton, Francis X. McGowan, Todd J. Kilbaugh
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Resuscitation Plus
Subjects:
Cardiac arrest
Cardiopulmonary resuscitation
Mitochondria
Fusion
Fission
Dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666520421000497

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http://www.sciencedirect.com/science/article/pii/S2666520421000497

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