Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs

Rabies remains an important worldwide public health threat, so safe, effective and affordable vaccines are still being sought. Virus-like particle (VLP)-based vaccines targeting various viral pathogens have been successfully produced, licensed and commercialized. Here, we designed and constructed tw...

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Bibliographic Details
Main Authors: Yinglin eQi, Hongtao eKang, Xuexing eZheng, Hualei eWang, Yuwei eGao, Songtao eYang, Xianzhu eXia
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Microbiology
Subjects:
Flagellin
Rabies virus
rabies vaccine
virus-like particle
LTB
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00169/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00169/full

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