Type II alveolar epithelial cell–specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4

Type II alveolar epithelial cell–specific loss of RhoA exacerbates allergic airway inflammation through SLC26A4

The small GTPase RhoA and its downstream effectors are critical regulators in the pathophysiological processes of asthma. The underlying mechanism, however, remains undetermined. Here, we generated an asthma mouse model with RhoA–conditional KO mice (Sftpc-cre;RhoAfl/fl) in type II alveolar epitheli...

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Bibliographic Details
Main Authors: Danh C. Do, Yan Zhang, Wei Tu, Xinyue Hu, Xiaojun Xiao, Jingsi Chen, Haiping Hao, Zhigang Liu, Jing Li, Shau-Ku Huang, Mei Wan, Peisong Gao
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-07-01
Series:JCI Insight
Subjects:
Immunology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.148147

Internet

https://doi.org/10.1172/jci.insight.148147

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