Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells

Secreted Stress-Induced Phosphoprotein 1 Activates the ALK2-SMAD Signaling Pathways and Promotes Cell Proliferation of Ovarian Cancer Cells

Stress-induced phosphoprotein 1 (STIP1), a cochaperone that organizes other chaperones, heat shock proteins (HSPs), was recently shown to be secreted by human ovarian cancer cells. In neuronal tissues, binding to prion protein was required for STIP1 to activate the ERK (extracellular-regulated MAP k...

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Bibliographic Details
Main Authors: Chia-Lung Tsai, Chi-Neu Tsai, Chiao-Yun Lin, Hsi-Wen Chen, Yun-Shien Lee, Angel Chao, Tzu-Hao Wang, Hsin-Shih Wang, Chyong-Huey Lai
Format: Article
Language:English
Published: Elsevier 2012-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712001982

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http://www.sciencedirect.com/science/article/pii/S2211124712001982

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