TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation

Loss of TDP-43 protein homeostasis and dysfunction, in particular TDP-43 aggregation, are tied to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). TDP-43 is an RNA binding protein tightly controlling its own expression levels through a negative feedback loop, involving TDP-43 r...

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Bibliographic Details
Main Authors: Lydia C. Koehler, Zachary R. Grese, Alliny C. S. Bastos, Lohany D. Mamede, Tomasz Heyduk, Yuna M. Ayala
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Neuroscience
Subjects:
TDP-43 (TAR DNA-binding protein 43)
RNA binding protein
ALS
frontotemporal dementia (FTD)
liquid-liquid phase separation (LLPS)
protein aggregation
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.818655/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.818655/full

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