Deepening the Knowledge of <i>ROS1</i> Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

Deepening the Knowledge of <i>ROS1</i> Rearrangements in Non-Small Cell Lung Cancer: Diagnosis, Treatment, Resistance and Concomitant Alterations

<i>ROS proto-oncogene 1 (ROS1)</i> rearrangements are reported in about 1–2% of non-squamous non-small-cell lung cancer (NSCLC). After efficacy of crizotinib was demonstrated, identification of <i>ROS1</i> translocations in advanced disease became fundamental to give patients...

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Bibliographic Details
Main Authors: Giorgia Guaitoli, Federica Bertolini, Stefania Bettelli, Samantha Manfredini, Michela Maur, Lucia Trudu, Beatrice Aramini, Valentina Masciale, Giulia Grisendi, Massimo Dominici, Fausto Barbieri
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
lung cancer
<i>ROS1</i> rearrangements
target therapies
molecular alterations
next generation sequencing
Online Access:https://www.mdpi.com/1422-0067/22/23/12867

Internet

https://www.mdpi.com/1422-0067/22/23/12867

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