The Role of PIM Kinases in Pediatric Solid Tumors
PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently availabl...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/14/15/3565 |
| _version_ | 1797432952747982848 |
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| author | Janet Rae Julson Raoud Marayati Elizabeth Ann Beierle Laura Lee Stafman |
| author_facet | Janet Rae Julson Raoud Marayati Elizabeth Ann Beierle Laura Lee Stafman |
| author_sort | Janet Rae Julson |
| collection | DOAJ |
| description | PIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials. |
| first_indexed | 2024-03-09T10:09:10Z |
| format | Article |
| id | doaj.art-19d32f87e7a94245b98b3abe3c4a5ac7 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T10:09:10Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-19d32f87e7a94245b98b3abe3c4a5ac72023-12-01T22:51:38ZengMDPI AGCancers2072-66942022-07-011415356510.3390/cancers14153565The Role of PIM Kinases in Pediatric Solid TumorsJanet Rae Julson0Raoud Marayati1Elizabeth Ann Beierle2Laura Lee Stafman3Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USADivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USADivision of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35233, USADivision of Pediatric Surgery, Department of Surgery, Vanderbilt University, Nashville, TN 37240, USAPIM kinases have been identified as potential therapeutic targets in several malignancies. Here, we provide an in-depth review of PIM kinases, including their structure, expression, activity, regulation, and role in pediatric carcinogenesis. Also included is a brief summary of the currently available pharmaceutical agents targeting PIM kinases and existing clinical trials.https://www.mdpi.com/2072-6694/14/15/3565PIM kinasepediatricneuroblastomahepatoblastomaosteosarcoma |
| spellingShingle | Janet Rae Julson Raoud Marayati Elizabeth Ann Beierle Laura Lee Stafman The Role of PIM Kinases in Pediatric Solid Tumors Cancers PIM kinase pediatric neuroblastoma hepatoblastoma osteosarcoma |
| title | The Role of PIM Kinases in Pediatric Solid Tumors |
| title_full | The Role of PIM Kinases in Pediatric Solid Tumors |
| title_fullStr | The Role of PIM Kinases in Pediatric Solid Tumors |
| title_full_unstemmed | The Role of PIM Kinases in Pediatric Solid Tumors |
| title_short | The Role of PIM Kinases in Pediatric Solid Tumors |
| title_sort | role of pim kinases in pediatric solid tumors |
| topic | PIM kinase pediatric neuroblastoma hepatoblastoma osteosarcoma |
| url | https://www.mdpi.com/2072-6694/14/15/3565 |
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