Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

Comparative effects of incretin-based therapy on doxorubicin-induced nephrotoxicity in rats: the role of SIRT1/Nrf2/NF-κB/TNF-α signaling pathways

Introduction: Nephrotoxicity represents a major complication of using doxorubicin (DOX) in the management of several types of cancers. Increased oxidative stress and the activation of inflammatory mediators play outstanding roles in the development of DOX-induced kidney damage. This study aimed to i...

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Bibliographic Details
Main Authors: Sandy R. Botros, Asmaa I. Matouk, Amr Amin, Gehan H. Heeba
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Pharmacology
Subjects:
doxorubicin
nephrotoxicity
incretins
glucagon-like peptide-1
dipeptidyl peptidase-4 inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1353029/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2024.1353029/full

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