Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.

Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation.

Tetrahydrobiopterin (BH₄) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. BH4 is unstable: during oxidative stress it is non-enzymatically oxidized to dihydrobiopterin (BH₂), which inhibits NOS. Dependi...

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Bibliográfalaš dieđut
Váldodahkkit: Tsin W Yeo, Daniel A Lampah, Enny Kenangalem, Emiliana Tjitra, Ric N Price, J Brice Weinberg, Keith Hyland, Donald L Granger, Nicholas M Anstey
Materiálatiipa: Artihkal
Giella:English
Almmustuhtton: Public Library of Science (PLoS) 2015-03-01
Ráidu:PLoS Pathogens
Liŋkkat:http://europepmc.org/articles/PMC4357386?pdf=render

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http://europepmc.org/articles/PMC4357386?pdf=render

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