Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway

Atorvastatin ameliorates lipid overload-induced mitochondrial dysfunction and myocardial hypertrophy by decreasing fatty acid oxidation through inactivation of the p-STAT3/CPT1 pathway

Although statins are shown to have cardiac pleiotropic effects independent of lowering cholesterol, the underlying mechanism remains unclear. Mitochondrial dysfunction induced by increased fatty acid oxidation (FAO) is the culprit in the development of cardiac hypertrophy and dysfunction. This study...

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Bibliographic Details
Main Authors: Peng Zheng, Hengfang Wu, Yilu Gu, Luo Li, Ran Hu, Wenjing Ma, Zhiping Bian, Nannan Liu, Di Yang, Xiangjian Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Atorvastatin
Myocardial hypertrophy
Fatty acid oxidation
Mitochondria
Carnitine palmitoyltransferase 1
Signal transducer and activator of transcription 3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222014135

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http://www.sciencedirect.com/science/article/pii/S0753332222014135

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