Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study

Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study

Background In rodents, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-dehydrocorticosterone to the active hormone corticosterone. Dysregulation of intracellular glucocorticoid action is implicated in metabolic diseases. Assessing 11β-HSD1 enzyme levels in vivo...

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Bibliographic Details
Main Authors: Jason Bini PhD, Jordan Strober PhD, Michael Kapinos BS, Ming-Qiang Zheng PhD, Songye Li PhD, Jim Ropchan PhD, Nabeel Nabulsi PhD, Yiyun Huang PhD, Rachel J. Perry PhD, Daniel F. Vatner MD, PhD, Richard E. Carson PhD
Format: Article
Language:English
Published: SAGE Publications 2024-12-01
Series:Molecular Imaging
Online Access:https://doi.org/10.1177/15353508241301584

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https://doi.org/10.1177/15353508241301584

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