The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

The expression of dominant negative TCF7L2 in pancreatic beta cells during the embryonic stage causes impaired glucose homeostasis

Objective: Disruption of TCF7L2 in mouse pancreatic β-cells has generated different outcomes in several investigations. Here we aim to clarify role of β-cell TCF7L2 and Wnt signaling using a functional-knockdown approach. Methods: Adenovirus-mediated dominant negative TCF7L2 (TCF7L2DN) expression wa...

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Bibliographic Details
Main Authors: Weijuan Shao, Xiaoquan Xiong, Wilfred Ip, Fenghao Xu, Zhuolun Song, Kejing Zeng, Marcela Hernandez, Tao Liang, Jianping Weng, Herbert Gaisano, M. Cristina Nostro, Tianru Jin
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Molecular Metabolism
Subjects:
GLP-1
GSIS
Pancreatic β-cells
TCF7L2
TCF7L2DN
Wnt
Incretin receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000216

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http://www.sciencedirect.com/science/article/pii/S2212877815000216

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