Acetylcholine Attenuated TNF-α-Induced Apoptosis in H9c2 Cells: Role of Calpain and the p38-MAPK Pathway

Acetylcholine Attenuated TNF-α-Induced Apoptosis in H9c2 Cells: Role of Calpain and the p38-MAPK Pathway

Background: Previous studies have shown that inflammation is associated with excessive activation of calpains. Acetylcholine (ACh) has been reported to inhibit pro-inflammatory cytokine release and protect against cardiomyocyte injury. However, there is no direct evidence regarding whether ACh can r...

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Bibliographic Details
Main Authors: Ming Zhao, Yang Yang, Xueyuan Bi, Xiaojiang Yu, Hanghuan Jia, Huanle Fang, Weijin Zang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Acetylcholine
Muscarinic receptor
Calpain
Calpastatin
p38-MAPK
Apoptosis
Online Access:http://www.karger.com/Article/FullText/430157

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