Experimental and bioinformatics considerations in cancer application of single cell genomics

Experimental and bioinformatics considerations in cancer application of single cell genomics

Single cell genomics offers an unprecedented resolution to interrogate genetic heterogeneity in a patient’s tumour at the intercellular level. However, the DNA yield per cell is insufficient for today’s sequencing library preparation protocols. This necessitates DNA amplification which is a key sour...

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Bibliographic Details
Main Authors: Joanna Hui Juan Tan, Say Li Kong, Joyce A. Tai, Huay Mei Poh, Fei Yao, Yee Yen Sia, Edwin Kok Hao Lim, Angela Maria Takano, Daniel Shao-Weng Tan, Asif Javed, Axel M. Hillmer
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Single cell genomics
Whole genome amplification
Single cell somatic variant caller
Protocol aware bioinformatics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037020305468

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http://www.sciencedirect.com/science/article/pii/S2001037020305468

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