Targeting Anion Exchange of Osteoclast, a New Strategy for Preventing Wear Particles Induced- Osteolysis

Targeting Anion Exchange of Osteoclast, a New Strategy for Preventing Wear Particles Induced- Osteolysis

Joint replacement is essential for the treatment of serious joint disease. However, prosthetic failure remains an important clinical issue, with periprosthesis osteolysis (PO), caused by osteoclastic bone resorption induced by wear particles, being the leading cause of failure. Nuclear factor of act...

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Bibliographic Details
Main Authors: Chuanlong Wu, Xuqiang Liu, Ruixin Sun, Yunhao Qin, Zhiqing Liu, Shengbing Yang, Tingting Tang, Zhenan Zhu, Degang Yu, Fengxiang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
bone resorption
wear particle
osteoclast
SLC4A2
actin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01291/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01291/full

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