Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

Human peroxiredoxin 6 is essential for malaria parasites and provides a host-based drug target

Summary: The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate that Plasmodium falciparum imports a host antioxida...

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Bibliographic Details
Main Authors: Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Cell Reports
Subjects:
CP: Microbiology
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722007008

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http://www.sciencedirect.com/science/article/pii/S2211124722007008

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